Overview
Optimizing downstream process development usually requires numerous iterations. Offline analytics are often a bottleneck for timely development. The antidote to lagging offline analytics is inline or online process analytical technology (PAT).
Real-time multi-angle light scattering (RT-MALS) is a PAT that monitors fundamental biophysical product attributes like molar mass, size, and titer, every second during downstream operations such as FPLC or UF/DF. For AAVs, RT-MALS also monitors the full capsid ratio. This webinar describes the technology of RT-MALS and its implementation with a variety of bioprocess unit operations and modalities, from proteins to viral vectors, LNPs, and pneumococcal vaccines.